The Zeller dataset contains information on the microbiome species abundance in healthy individuals and colorectal cancer patients (doi: 10.15252/msb.20145645) and was used for the SIMON analysis as described (https://doi.org/10.1101/2020.08.16.252767). The data was access through MetagenomicData package as described by Pasolli and colleagues (doi: 10.1038/nmeth.4468). In total 184 individuals were included of which 93 were healthy controls and 91 colorectal cancer patients.