资源介绍
Objective: Vitamin D deficiency was previously correlated with incidence and severity of COVID-19. We investigated the correlation between serum?25(OH)D level on admission and radiological stage and outcome of COVID-19 pneumonia.?
Methods: Retrospective observational trial on 186 SARS-CoV-2-infected individuals hospitalized from March 1, 2020 to April 7, 2020 with combined chest CT and 25(OH)D measurement on admission. Multivariate analysis was performed to study if vitamin D deficiency (25(OH)D < 20 ng/mL) predicts survival independently of confounding comorbidities.?
Results: 59% of COVID-19 patients were vitamin D deficient on admission: 47% of females and 67% of males. Particularly male COVID-19 patients showed progressively lower 25(OH)D with advancing radiological stage, with deficiency rates increasing from 55% in stage 1 to 74% in stage 3. Vitamin D deficiency on admission was not confounded by age, chronic lung disease, coronary artery disease/hypertension or diabetes and was correlated with mortality (OR=3.87, 95%CI 1.30-11.55), independently of other predictors including age (OR=1.09, 95%CI 1.03-1.14), chronic lung disease (OR=3.61, 95% CI 1.18-11.09) and extent of lung damage expressed by chest CT severity score (1.12, 95% CI 1.01-1.25).?
Conclusions: low 25(OH)D levels on admission are associated with COVID-19 disease mortality
